Technology

The iodine window.

Enough free iodine to kill bacteria, biofilm, viruses and fungi — below the level that harms the keratinocytes and fibroblasts that close the wound. IothaFoam is engineered to hold the wound inside that window, for days.

Macro view of amber open-cell polyurethane foam (illustrative)
Mechanism

How it works, in three steps.

1
A reservoir of iodine

Medical polyurethane open-cell foam, laminated to a breathable film, holds iodine in its cells. Supplied moist in a sealed pouch; cut to size and used like any foam dressing.

2
Slow, steady release

Iodine moves from the foam into the wound bed at a controlled rate — enough to act on biofilm, low enough to spare healing tissue. Days between changes, not hours.

3
No documented acquired resistance

Iodine attacks multiple targets at once, so the resistance and cytotoxicity problems that limit silver do not apply.

Microbiology bench testing of foam samples (illustrative)
The insight

There is a window where iodine kills bacteria and spares the cells that heal.

Below it, iodine does too little. Above it, it harms tissue. Nobody had built a dressing that stays inside the window for days.

THE IODINE WINDOWBacteria & biofilm killedHealing cells viableTOO LITTLE TO KILL BACTERIATOO MUCH, HARMS TISSUEFREE IODINE CONCENTRATION →
Conceptual illustration based on published kill and cell-viability data (Bigliardi et al., Int J Surg 2017). Patent pending, US 2025/0064645 A1.
Technical drawing: cross-section of the dressing on the wound
On the wound

Built for the wound bed, where biofilm lives.

The breathable polyurethane film keeps the wound moist and blocks outside bacteria. Beneath it, the iodinated foam sits directly on the wound bed and releases iodine into it.

The material

Iodine held in open cells.

The foam's open-cell structure is what lets IothaFoam store iodine and release it over days, rather than dumping it at application.

Technical drawing: magnified view of the open-cell foam holding iodine
Why iodine, why now

Everyone else trades one for the other.

SilverPovidone-iodinePlain foamIothaFoam
Established biofilmWeakToo little free iodine to reach itNot addressedDesigned to clear it
Healing cellsToxic to keratinocytes and fibroblastsHarsh at high concentrationGentleRelease held below the level that harms them
ResistanceNow documentedNone documented—No documented acquired resistance
DurationDaysShort-livedDaysDays between changes, not hours
Company assessment based on published cytotoxicity, resistance and release data; not cleared claims. Khansa 2019; Hosny 2019 (silver) · Wada 2016 (povidone-iodine free iodine).
Intellectual property

Decades of iodine–polyurethane science.

Patent pending: US 2025/0064645 A1, the iodine-window dressing.

Prior work: the founder's earlier iodine–polyurethane patents, and published research on self-sterilizing plastics formed by complexing polyurethane and iodine (LeVeen et al., Surgery, Gynecology & Obstetrics, 1993).

In progress: a catheter application on the same platform.

See the platform and patents →

IOTHANE MEDICAL
1515 El Camino Real, Suite D, Palo Alto, CA 94306
CAUTION: IothaFoam™ is an investigational device. It has not been cleared or approved by the U.S. Food and Drug Administration and is not available for sale.
IothaFoam™ is a trademark of IOTHANE Medical, Inc. Patent pending (US 2025/0064645 A1). Content on this site is for general information only and is not medical advice. Images are illustrative.
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